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KMID : 0361019980410070901
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Korean Journal of Otolaryngology - Head and Neck Surgery
1998 Volume.41 No. 7 p.901 ~ p.905
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Expression of p16 Protein and Cyclin D1 Protein in Head and Neck Squamous Cell Carcinomas
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Abstract
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Background and Objectives: The p16, cyclin D1, their partners Cdk4/Cdk6, and pRb constitute a G1 regulatory pathway comonly targeted in tumorigenesis. Genetical, immunochemical, and funcitnal analyses show abnormalities of this pathway in
various
tumors including head and neck squmaous cell carcinoma. To invesigate the clinicopathologic meanings of p16 protein and the relationship between p16 and cyclin D1 in head and neck squmous cell carcinoma. Materials and Methods:
Formalin-fixed
paraffin-embeded tumor materials that were obtained from 37 patient with head and neck squmaous cell carcinoma were analyzed by immunohistochemical staining method using antiserum that were directed against p16 and cyclin D1. Results: 1)
Deletion
of p16 was found in 67.6%(25/37) of the patients with head and neck squamous cell carcinoma. The deletion was not associated with the clinicopathologic parameters (eg. T and N stages, cell differentiation). 2) Deletion of p16 protein and
overexpressin
of cyclin D1 were identified in 76%(28/37) of the patients with head and neck squmaous cell carcinoma. But deletion of p16 was not affected by the overexpression of cyclin D1 in head and neck squmaous cell carcinoma. Conclusion: Deletion
of
p16
and overexpression of cyclin D1 were identified in head and neck squmaous cell carcoinoma. These may abrogate the G1 regulatory pathway. These data suggested that combination of these abnormalities may be important in head and neck
turmorigenesis.
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KEYWORD
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